Breaking Down Different Types of Neurotoxins: Botox, Xeomin, Dysport, Jeuveau, and Daxxify

April 21, 2025

woman receiving botox for wrinkles

An all-encompassing guide to the pros and cons of each, according to expert injectors.

Long gone are the days of brand-name Botox being the only injectable available to those looking to stave off fine lines and wrinkles. Sure, Botox is the OG and synonymous with neurotoxins as a whole (it’s like the Q-Tip of the cotton swab category or the Kleenex of tissues). In recent years, several other big players have joined the neurotoxin space, and while it’s great to have options, it can be hard to determine which is the best for you—especially when each brand makes big, bold claims about the superiority of their product. Here’s a break through sharing experiences with Botox, Xeomin, Jeuveau, Dysport, and Daxxify, and tapping expert injectors to detail the pros and cons of each one.

Dr. Jody Comstock, Board-Certified Dermatologist at U.S. Dermatology Partners Skin Spectrum, was recently featured in an in-depth article by Cosmopolitan discussing the pros and cons of each. Dr. Comstock shared insights into the newest neurotoxin, Daxxify, and what sets it apart.

Daxxify

Daxxify is the newest player in the neurotoxin space, with its FDA approval arriving in late 2022. The major difference with this injectable lies in its formulation. “The others use human serum albumin (HSA), which is of course human derived,” says Jody Comstock, MD, a board-certified dermatologist at U.S. Dermatology Partners’ Skin Spectrum. “Daxxify is differentiated because it uses peptides in place of the HSA.” Many injectors believe this is the difference that allows Daxxify to deliver softer, gentler, and more natural-looking results, a characteristic that has been confirmed in clinical trials. “With Daxxify, we noticed incredible skin, tone, and texture improvement and decreased size of pores—my colleague calls it the ‘beautiful toxin,’” Dr. Comstock adds.

What really sets Daxxify apart from other neurotoxins, however, is how long it lasts. Results usually start to take effect within three days and develop fully by the two-week mark, but they can last six to nine months, the longest duration of any toxin on the market. In my experience, Daxxify actually kicks in the fastest of any injectable I’ve tried and does have a much smoother look than the others, but I can’t say it lasted quite so long for me. Both times I’ve tried Daxxify, I noticed it starting to wear off right around four-and-a-half months.

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